• Corpus ID: 53688634

The danger of excessive vaccination during brain development: the case for a link to Autism Spectrum Disorders (ASD)

@inproceedings{Blaylock2008TheDO,
  title={The danger of excessive vaccination during brain development: the case for a link to Autism Spectrum Disorders (ASD)},
  author={Russell L. Blaylock},
  year={2008}
}

• R. Blaylock
• Published 2008
• Biology

The incidence of postnatal (regressive) autism has increased dramatically, since the mid-1980s. A number of studies have related this rise in incidence of Autism Spectrum Disorder (ASD) diagnoses to increases in the number of vaccines added to the childhood immunization schedule at this same time. Despite an intensive effort to identify the causation of this disorder, little has been offered in terms of a central causal mechanism. A number of observations have been made concerning alteration in immune system function, abnormal organic acid synthesis, mercury toxicity, and gliamorphin effects on cerebral function. Yet, none of these adequately explains the relationship to vaccinations. A compelling amount of research has shown that repeated stimulation of the systemic immune system results in first priming of the microglia in the developing brain, followed by an intense microglial reaction with each successive series of vaccinations. Because of the critical dependence of the developing brain on a timed sequence of cytokine and excitatory amino acid fluctuation, sequential vaccination can result in alterations in this critical process that will not only result in synaptic and dendritic loss, but abnormal pathway development. When activated, especially chronically, microglia, the resident immune cell of the brain, secretes a number of inflammatory cytokines, free radicals, lipid peroxidation products, and two excitotoxins—glutamate and quinolinic acid. This evidence suggests that this central mechanism results in the pathological as well as clinical features of autism.