The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites.

@article{Kim2011TheDT,
  title={The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites.},
  author={Nayun Kim and Sarah Victoria Mudrak and Sue Jinks-Robertson},
  journal={DNA repair},
  year={2011},
  volume={10 12},
  pages={
          1262-71
        }
}
The bypass of AP sites in yeast requires the Rev1 protein in addition to the Pol ζ translesion synthesis DNA polymerase. Although Rev1 was originally characterized biochemically as a dCMP transferase during AP-site bypass, the relevance of this activity in vivo is unclear. The current study uses highly sensitive frameshift- and nonsense-reversion assays to monitor the bypass of AP sites created when uracil is excised from chromosomal DNA. In the frameshift-reversion assay, an unselected base… CONTINUE READING
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