The d3/fl-growth hormone (GH) receptor polymorphism does not influence the effect of GH treatment (66 microg/kg per day) or the spontaneous growth in short non-GH-deficient small-for-gestational-age children: results from a two-year controlled prospective study in 170 Spanish patients.

@article{Carrascosa2006TheDH,
  title={The d3/fl-growth hormone (GH) receptor polymorphism does not influence the effect of GH treatment (66 microg/kg per day) or the spontaneous growth in short non-GH-deficient small-for-gestational-age children: results from a two-year controlled prospective study in 170 Spanish patients.},
  author={Antonio Abad Carrascosa and Cristina Esteban and Rosa Mar{\'i}a Espadero and M{\'o}nica Fern{\'a}ndez-Cancio and Pilar Andaluz and Mar{\'i}a Clemente and Laura Aud{\'i} and Hartmut Wollmann and Linda Fryklund and Luis Parodi},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 9},
  pages={3281-6}
}
CONTEXT The d3/fl-GH receptor (d3/fl-GHR, exon 3-deleted/full-length GHR) has recently been associated with responsiveness to GH therapy. OBJECTIVE The objective of the study was to evaluate whether the d3/fl-GHR genotypes influence the intensity of spontaneous and/or GH therapy-stimulated growth in small-for-gestational-age (SGA) patients. DESIGN This was a 2-yr prospective, controlled, randomized trial. SETTING Thirty Spanish hospitals participated. Auxologic and GH secretion evaluation… CONTINUE READING

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