The cytotoxicity of γ-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by γ-secretase inhibition

@article{Han2009TheCO,
  title={The cytotoxicity of γ-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by γ-secretase inhibition},
  author={Jianxun Han and Ivy Ma and Michael J. Hendzel and Joan Allalunis-Turner},
  journal={Breast Cancer Research : BCR},
  year={2009},
  volume={11},
  pages={R57 - R57}
}
Notch is a family of transmembrane protein receptors whose activation requires proteolytic cleavage by γ-secretase. Since aberrant Notch signaling can induce mammary carcinomas in transgenic mice and high expression levels of Notch receptors and ligands correlates with overall poor clinical outcomes, inhibiting γ-secretase with small molecules may be a… CONTINUE READING