The cytotoxicity and mechanisms of 1,2-naphthoquinone thiosemicarbazone and its metal derivatives against MCF-7 human breast cancer cells.

@article{Chen2004TheCA,
  title={The cytotoxicity and mechanisms of 1,2-naphthoquinone thiosemicarbazone and its metal derivatives against MCF-7 human breast cancer cells.},
  author={Junnan Chen and Yue-Wern Huang and Guanshu Liu and Zahra Afrasiabi and Ekkehard Sinn and Subhash B. Padhye and Yinfa Ma},
  journal={Toxicology and applied pharmacology},
  year={2004},
  volume={197 1},
  pages={
          40-8
        }
}

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References

SHOWING 1-10 OF 104 REFERENCES
Synthesis, structure, spectroscopy and antitumor activity of hydroxy naphthoquinone thiosemicarbazone and its metal complexes against MCF-7 human breast cancer cell line
Coordinately unsaturated metal complexes of the stoichiometry [M(HL)Cl] and [Fe(HL)Cl 2 ].2H 2 O have been isolated (where M=Cu(II), Ni(II), Pd(II) and Pt(II); HL=tridentate anion of H 2 L 3). The
[Cytotoxicity of beta-lapachone, an naphthoquinone with possible therapeutic use].
TLDR
Advances in knowledge of apoptosis ("programmed cell death") and necrosis provided useful information for understanding the mechanism of beta-lap cytotoxicity.
DNA damage and cytotoxicity induced by beta-lapachone: relation to poly(ADP-ribose) polymerase inhibition.
The Cytotoxicity of 2‐Formyl and 2‐Acetyl‐(6‐picolyl)‐4N‐Substituted Thiosemicarbazones and Their Copper(II) Complexes
2‐Acetyl‐(6‐picolyl)‐4N‐substituted thiosemicarbazones and their copper(II) complexes were shown to be potent antineoplastic and cytotoxic agents against murine and human cultured cells. Numerous
Novel, quinone-thiosemicarbazone hybrid (QTSCHY) non-platinum antitumor agents: inhibition of DNA biosynthesis in P388 lymphocytic cells by coordinatively unsaturated copper(II) and iron(III) complexes of naphthoquinone thiosemicarbazones
Coordinately unsaturated Cu(II) and Fe(III) complexes of the stoichiometry [Cu(L)Cl] and [Fe(L)Cl2], where L=tridentate anion of 2-hydroxy-1,4-naphthoquinone 1-thiosemicarbazone (2HNQTSC) and its
Relationship between lethal effects and topoisomerase II-mediated double-stranded DNA breaks produced by anthracyclines with different sequence specificity.
TLDR
The results suggest that the cytotoxic potency of anthracyclines may be the result of an interplay of the level, the persistence, and the genomic localization of topoisomerase II-mediated DNA cleavage.
Syntheses and antitumor activities of potent inhibitors of ribonucleotide reductase: 3-amino-4-methylpyridine-2-carboxaldehyde-thiosemicarba-zone (3-AMP), 3-amino-pyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) and its water-soluble prodrugs.
TLDR
3-AP prodrugs prepared indeed demonstrated improved pharmaceutical, biological and toxicity profiles over the parent 3-AP when evaluated against the murine M-109 lung carcinoma as well as the B16-F10 murine melanoma xenograft models, and the newly prepared phosphate pro drugs displayed improved efficacy and safety profiles than that found with the parent.
...
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