The cytotoxic principles of Solanum incanum.

Abstract

In continuation of work on Solanum incanum a new steroidal alkaloid glycoside has been isolated from the fresh berries, which is named incanumine, and characterized as O(3)-[beta-D-xylopyranosyl-(1----3glu)-[beta-D-xylopyranosyl-(1--- -4rha)- alpha-L-rhamnopyranosyl-(1----4)]-beta-D-glucopyranosyl)-solasodine++ +. Solamargine, solasodine, ursolic acid, and ursolic acid derivatives (3-O-palmitoyl ursolic acid, 3-O-crotonyl ursolic acid, 3-O-propionyl ursolic acid) exhibited significant cytotoxic effects against human PLC/PRF/5 cells in vitro. Esterification of ursolic acid with aliphatic acids clearly enhanced the cytotoxic effects against human PLC/PRF/5 cells in vitro.

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@article{Lin1990TheCP, title={The cytotoxic principles of Solanum incanum.}, author={Chien Nan Lin and Connie M. Lu and Monica K Cheng and Kah Hui Gan and Seok Joon Won}, journal={Journal of natural products}, year={1990}, volume={53 2}, pages={513-6} }