The cytotoxic anti-tumor effect of MTH-68/H, a live attenuated Newcastle disease virus is mediated by the induction of nitric oxide synthesis in rat peritoneal macrophages in vitro.

@article{Hrabk2006TheCA,
  title={The cytotoxic anti-tumor effect of MTH-68/H, a live attenuated Newcastle disease virus is mediated by the induction of nitric oxide synthesis in rat peritoneal macrophages in vitro.},
  author={Andr{\'a}s Hrab{\'a}k and Ildik{\'o} Csuka and Tam{\'a}s Bajor and Laszlo K. Csatary},
  journal={Cancer letters},
  year={2006},
  volume={231 2},
  pages={279-89}
}
Rat peritoneal macrophages were induced to produce high amounts of nitric oxide (NO) when rats were challenged by MTH68/H, (a live attenuated oncolytic Newcastle disease virus strain). The increase in NO production was observed to be viral particle dose dependent. The higher NO production measured could be due to the enhanced expression of NO synthase II enzyme. In addition, viral administration caused a higher macrophage cell count in the peritoneal cavity of treated rats. Interleukin-1 and… CONTINUE READING

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