The cytotoxic activity of ursolic acid derivatives.

  title={The cytotoxic activity of ursolic acid derivatives.},
  author={Chao-Mei Ma and Shao-Qing Cai and Jing-rong Cui and Rui-qing Wang and Pengfei Tu and Masao Hattori and Mohsen Daneshtalab},
  journal={European journal of medicinal chemistry},
  volume={40 6},
Ursolic acid and 2alpha-hydroxyursolic acid isolated from apple peels were found to show growth inhibitory activity against four tumor cell lines, HL-60, BGC, Bel-7402 and Hela. Structural modifications were performed on the C-3, C-28 and C-11 positions of ursolic acid and the cytotoxicity of the derivatives was evaluated. The SAR revealed that the triterpenes possessing two hydrogen-bond forming groups (an H-donor and a carbonyl group) at positions 3 and 28 exhibit cytotoxic activity. The… CONTINUE READING

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