The cytosolic termini of the beta- and gamma-ENaC subunits are involved in the functional interactions between cystic fibrosis transmembrane conductance regulator and epithelial sodium channel.

@article{Ji2000TheCT,
  title={The cytosolic termini of the beta- and gamma-ENaC subunits are involved in the functional interactions between cystic fibrosis transmembrane conductance regulator and epithelial sodium channel.},
  author={H L Ji and Michael L Chalfant and Biljana Jovov and Jane Lockhart and Samuel B Parker and Catherine M. Fuller and Bruce A. Stanton and Dale J. Benos},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 36},
  pages={27947-56}
}
Epithelial sodium channel (ENaC) and cystic fibrosis transmembrane conductance regulator (CFTR) are co-localized in the apical membrane of many epithelia. These channels are essential for electrolyte and water secretion and/or reabsorption. In cystic fibrosis airway epithelia, a hyperactivated epithelial Na(+) conductance operates in parallel with defective Cl(-) secretion. Several groups have shown that CFTR down-regulates ENaC activity, but the mechanisms and the regulation of CFTR by ENaC… CONTINUE READING