The cytosolic domains of Ca2+-sensitive adenylyl cyclases dictate their targeting to plasma membrane lipid rafts.

@article{Crossthwaite2005TheCD,
  title={The cytosolic domains of Ca2+-sensitive adenylyl cyclases dictate their targeting to plasma membrane lipid rafts.},
  author={Andrew J Crossthwaite and Thomas Seebacher and Nanako Masada and Antonio Ciruela and Kim Dufraux and Joachim E Schultz and Dermot M F Cooper},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 8},
  pages={
          6380-91
        }
}
Lipid rafts are specialized, cholesterol-rich domains of the plasma membrane that are enriched in certain signaling proteins, including Ca(2+)-sensitive adenylyl cyclases. This restrictive localization plays a key role in the regulation of the Ca(2+)-stimulable AC8 and the Ca(2+)-inhibitable AC6 by capacitative calcium entry. Interestingly, AC7, a Ca(2+)-insensitive AC, is found in the plasma membrane but is excluded from lipid rafts (Smith, K. E., Gu, C., Fagan, K. A., Hu, B., and Cooper, D. M… CONTINUE READING
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