The cytoskeletal network controls c-Jun expression and glucocorticoid receptor transcriptional activity in an antagonistic and cell-type-specific manner.

@article{Oren1999TheCN,
  title={The cytoskeletal network controls c-Jun expression and glucocorticoid receptor transcriptional activity in an antagonistic and cell-type-specific manner.},
  author={Anat Oren and Avia Herschkovitz and Iris Ben-Dror and Vered Holdengreber and Yehuda Ben-Shaul and Rony Seger and Lily Vardimon},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 3},
  pages={1742-50}
}
The physical and functional link between adhesion molecules and the cytoskeletal network suggests that the cytoskeleton might mediate the transduction of cell-to-cell contact signals, which often regulate growth and differentiation in an antagonistic manner. Depolymerization of the cytoskeleton in confluent cell cultures is reportedly sufficient to initiate DNA synthesis. Here we show that depolymerization of the cytoskeleton is also sufficient to repress differentiation-specific gene… CONTINUE READING