The cytoprotective protein C pathway.

  title={The cytoprotective protein C pathway.},
  author={Laurent O Mosnier and Berislav V Zlokovic and John H. Griffin},
  volume={109 8},
Protein C is best known for its mild deficiency associated with venous thrombosis risk and severe deficiency associated with neonatal purpura fulminans. Activated protein C (APC) anticoagulant activity involves proteolytic inactivation of factors Va and VIIIa, and APC resistance is often caused by factor V Leiden. Less known is the clinical success of APC… CONTINUE READING