The cytoplasmic side of p53's oncosuppressive activities.

  title={The cytoplasmic side of p53's oncosuppressive activities.},
  author={Anna Comel and Giovanni Sorrentino and Valeria Capaci and Giannino Del Sal},
  journal={FEBS letters},
  volume={588 16},
The tumor suppressor p53 is a transcription factor that in response to a plethora of stress stimuli activates a complex and context-dependent cellular response ultimately protecting genome integrity. In the last two decades, the discovery of cytoplasmic p53 localization has driven an intense research on its extra-nuclear functions. The ability to induce apoptosis acting directly at mitochondria and the related mechanisms of p53 localization and translocation in the cytoplasm and mitochondria… CONTINUE READING