The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.

@article{Wood1993TheCR,
  title={The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.},
  author={K. Wood and Haiqing Qi and G V D'arcangelo and Robert C. Armstrong and Thomas M Roberts and Simon Halegoua},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 11},
  pages={5016-20}
}
The neuron-like differentiation of PC12 cells is induced by nerve growth factor (NGF) through stimulation of a membrane-bound protooncoprotein signaling pathway containing the NGF receptor Trk, the tyrosine kinase Src, and the GTP-binding protein Ras. The Raf-1 and B-raf protooncogenes encode cytoplasmic serine/threonine kinases that are stimulated by NGF in a Ras-dependent manner. To investigate the possible roles of cytoplasmic Raf kinases in eliciting neuronal differentiation, we have… CONTINUE READING

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