The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

@article{Cals1988TheCP,
  title={The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product},
  author={Carmela Cal{\'e}s and John F Hancock and Christopher J. Marshall and Alan G Hall},
  journal={Nature},
  year={1988},
  volume={332},
  pages={548-551}
}
About 30% of human tumours contain a mutation in one of the three ras genes leading to the production of p21ras oncoproteins that are thought to make a major contribution to the transformed phenotype of the tumour1,2. The biochemical mode of action of the ras proteins is unknown but as they bind GTP and GDP and have an intrinsic GTPase activity, they may function like regulatory G proteins3–7 and control cell proliferation by regulating signal transduction pathways at the plasma membrane8–10… CONTINUE READING