The cytoplasmic polyadenylation element binding protein and polyadenylation of messenger RNA in Aplysia neurons.

@article{Liu2003TheCP,
  title={The cytoplasmic polyadenylation element binding protein and polyadenylation of messenger RNA in Aplysia neurons.},
  author={Jinming Liu and James H. Schwartz},
  journal={Brain research},
  year={2003},
  volume={959 1},
  pages={68-76}
}
Translation of some mRNAs in nerve terminals has been shown to be regulated by polyadenylation in an experience-dependent manner. The transcripts whose translation is controlled by regulated polyadenylation contain the cytoplasmic polyadenylation element (CPE), which binds to the highly conserved CPE-binding protein (CPEB). In Aplysia, neuron-specific actin mRNA, which has a CPE in its 3' UTR, is located both in cell bodies and at nerve endings (synaptosomes). We found that actin mRNA from… CONTINUE READING

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