The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

@article{Irving1991TheCD,
  title={The cytoplasmic domain of the T cell receptor $\zeta$ chain is sufficient to couple to receptor-associated signal transduction pathways},
  author={B. Irving and A. Weiss},
  journal={Cell},
  year={1991},
  volume={64},
  pages={891-901}
}
The function of the T cell antigen receptor (TCR) invariant chains, CD3 gamma, delta, epsilon, and zeta, is poorly understood. Evidence suggests that CD3 couples receptor ligand binding to intracellular signaling events. To examine the role of the CD3 zeta chain in TCR-mediated signal transduction, a chimeric protein linking the extracellular and transmembrane domains of CD8 to the cytoplasmic domain of the zeta chain was constructed. The CD8/zeta chimera is expressed independently of the TCR… Expand
The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules
TLDR
This work constructed TCR/CD3 complexes devoid of functional zeta subunit and showed that they are still able to trigger the production of interleukin-2 in response to antigen or superantigen and individualized a functional domain that may have constituted the building block of most of the transducing subunits associated with antigen receptors and some Fc receptors. Expand
The TCR zeta-chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes.
TLDR
The results show that the zeta-chain ITAMs, in the absence of the gamma, delta, and epsilon ITams, are sufficient for the activation and functional maturation of primary T lymphocytes, and supports the isolated use of the zetas in the development of surrogate TCRs for therapeutic purposes. Expand
Insights into T cell development and signal transduction provided by TCR-zeta chain deficient mice.
TLDR
Results from the generation and analysis of zeta deficient and zeta-transgenic mice are discussed which suggest distinct roles for zeta chain and the CD3 components at different stages of T cell development. Expand
Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes
TLDR
It is demonstrated that the cytoplasmic portion of the TCR-zeta chain is not sufficient to activate resting T lymphocytes when cells from transgenic mice expressing a chimeric zeta receptor are used, suggesting that the triggering requirements for effector functions seem to be different in resting than in activated T cells. Expand
Development and function of T cells in T cell antigen receptor/CD3 ζ knockout mice reconstituted with FcɛRI γ
TLDR
The results showed that substitution of FcRγ for ζ allows T cell development and does not inevitably create nonresponsive T cells, and the role of ζ in TCR expression and thymocyte development is examined. Expand
The short length of the extracellular domain of zeta is crucial for T cell antigen receptor function.
TLDR
It is shown that TCR-CD3 assembly is clearly defective when the murine zeta EC domain is artificially enlarged, leading to a hyperactive phenotype and enhanced T cell activation and data suggest that a short zetaEC domain is needed to correctly assemble the T CR- CD3 complex. Expand
Sequence requirements for induction of cytolysis by the T cell antigen Fc receptor ζ chain
TLDR
Analysis of individual amino acids within the 18 residue element reveals two phylogenetically conserved tyrosines that are absolutely required for activity and other residues that are less essential but contribute to the efficacy of receptor-directed cytolysis. Expand
The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation
TLDR
The data directly establish the CD3 zeta cytoplasmic domain as a necessary and sufficient component of theCD3-Ti complex involved in T lymphocyte activation through CD2 and show that CD2 signaling can function in the absence of Fc receptors. Expand
T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.
  • F. Letourneur, R. Klausner
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1991
TLDR
The zeta and gamma chimera were effective at eliciting interleukin 2 production in T cells and serotonin release in rat basophilic leukemia cells when externally cross-linked. Expand
T-cell receptor signal transmission: who gives an ITAM?
TLDR
Two non-exclusive models of TCR signal transduction are incorporated: the ITAM multiplicity model, which describes a functional redundancy within the TCR zeta and CD3 ITAMs; and the differential signalingmodel, which proposes distinct functions for the CD3-gamma, -delta and -epsilon and TCRZeta modules. Expand
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References

SHOWING 1-10 OF 58 REFERENCES
The structure and signalling functions of the invariant T cell receptor components.
TLDR
The zeta chain is implicated as uniquely coupling TCR antigen engagement to distal IL-2 signalling, perhaps via activation of the tyrosine kinase pathway. Expand
Failure to synthesize the T Cell CD3-ζ chain: Structure and function of a partial T cell receptor complex
TLDR
Surprisingly, in the absence of CD3-zeta, direct cross-linking of the partial receptor induced both phosphatidylinositol hydrolysis and interleukin 2 production, which indicates that CD3/Ti determines the normal intracellular fate of the T cell antigen receptor. Expand
Structural mutations of the T cell receptor zeta chain and its role in T cell activation.
T cell hybridomas that express zeta zeta, but not zeta eta, dimers in their T cell receptors (TCRs) produce interleukin-2 (IL-2) and undergo an inhibition of spontaneous growth when activated byExpand
Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization.
The T-cell antigen receptor (TcR) complex present on most T-cells is formed by a clone-specific disulfide-linked alpha/beta heterodimer noncovalently associated to the CD3 complex, the latterExpand
Disulfide linkage of the zeta and eta chains of the T cell receptor. Possible identification of two structural classes of receptors.
TLDR
The tight regulation of the zeta-zeta toZeta-eta ratio suggests an important functional role for these structural components of the TCR. Expand
Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.
TLDR
It is demonstrated that antibodies binding extracellular but not intracellular domains of the TCR specifically coprecipitate only the fyn PTK and not lck or yes, two other kinases found in these cells. Expand
T cell CD3-zeta eta heterodimer expression and coupling to phosphoinositide hydrolysis.
The T cell antigen receptor consists of an antigen-binding heterodimer that is noncovalently associated with at least five CD3 subunits (gamma, delta, epsilon, zeta, and eta). The CD3-zeta chains areExpand
Family of disulphide-linked dimers containing the ζ and η chains of the T-cell receptor and the γ chain of Fc receptors
STIMULATION of T cells by antigen activates many signalling pathways1. The capacity for this range of biochemical responses may reside in the complex structure of the seven-chain T-cell antigenExpand
Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies.
TLDR
To determine directly whether zeta limits receptor assembly, a zeta‐deficient T cell line is reconstituted by transfection of the murine zeta cDNA and increasing zeta expression results in a commensurate increase in the survival of previously excess subunits. Expand
The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.
TLDR
It is demonstrated that LFA-3 under appropriate conditions can activate T cells via the CD2 complex and that this activation requires not only the cell surface expression of the CD3/Ti complex but also a functional Ag receptor pathway. Expand
...
1
2
3
4
5
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