The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein trafficking

@article{Gilberger2003TheCD,
  title={The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein trafficking},
  author={Tim-Wolf Gilberger and Jennifer K. Thompson and Michael B. Reed and R. T. Good and Alan F Cowman},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={162},
  pages={317 - 327}
}
The invasion of host cells by the malaria parasite Plasmodium falciparum requires specific protein-protein interactions between parasite and host receptors and an intracellular translocation machinery to power the process. The transmembrane erythrocyte binding protein-175 (EBA-175) and thrombospondin-related anonymous protein (TRAP) play central roles in this process. EBA-175 binds to glycophorin A on human erythrocytes during the invasion process, linking the parasite to the surface of the… CONTINUE READING