The cytoplasmic C-terminus of polycystin-1 increases cell proliferation in kidney epithelial cells through serum-activated and Ca(2+)-dependent pathway(s).

@article{Manzati2005TheCC,
  title={The cytoplasmic C-terminus of polycystin-1 increases cell proliferation in kidney epithelial cells through serum-activated and Ca(2+)-dependent pathway(s).},
  author={Elisa Manzati and Gianluca Aguiari and Manuela Banzi and Michele Manzati and Rita Selvatici and Sofia Falzarano and Iva Maestri and Paolo Pinton and Rosario Rizzuto and Laura del Senno},
  journal={Experimental cell research},
  year={2005},
  volume={304 2},
  pages={391-406}
}
Polycystin-1 (PC1) is a large transmembrane protein important in renal differentiation and defective in most cases of autosomal dominant polycystic kidney disease (ADPKD), a common cause of renal failure in adults. Although the genetic basis of ADPKD has been elucidated, molecular and cellular mechanisms responsible for the dysregulation of epithelial cell growth in ADPKD cysts are still not well defined. We approached this issue by investigating the role of the carboxyl cytoplasmic domain of… CONTINUE READING