The cytopathic effect of human immunodeficiency virus is independent of high levels of unintegrated viral DNA accumulated in response to superinfection of cells.

@article{LaurentCrawford1993TheCE,
  title={The cytopathic effect of human immunodeficiency virus is independent of high levels of unintegrated viral DNA accumulated in response to superinfection of cells.},
  author={A. G. Laurent-Crawford and Ara G. Hovanessian},
  journal={The Journal of general virology},
  year={1993},
  volume={74 ( Pt 12)},
  pages={2619-28}
}
Large quantities of genome-sized viral DNA are detected in the nucleoplasm of CD4+ T cells infected with human immunodeficiency virus type 1 (HIV-1). This unintegrated HIV DNA is in the form of both circular and linear species. Accumulation of such DNA occurs gradually during a 5 day HIV infection and is correlated with the proportion of cells involved in the production of HIV proteins. To pinpoint the stage in a synchronized HIV infection during which accumulation of HIV DNA occurs, high… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Inhibition of entry of HIV particles in cells by poly(A), poly(U)

  • G.A.
  • AIDS Research and Human Retroviruses (in press…
  • 1993

Antiviral action of polyadenylic-polyuridylic acid against HIV in cell cultures

  • G.A.
  • AIDS Research and Human Retroviruses 8, 285 290…
  • 1992

Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction

  • M. SACHS, R. J. POMERANTZ
  • New England Journal of Medicine
  • 1992

Similar Papers

Loading similar papers…