The cytopathic effect of HIV is associated with apoptosis.

@article{LaurentCrawford1991TheCE,
  title={The cytopathic effect of HIV is associated with apoptosis.},
  author={Anne-G. Laurent-Crawford and Bernard Krust and S Schnepp Wfo Muller and Yves Rivi{\'e}re and M A Rey-Cuill{\'e} and Jean Marie Bechet and Luc Montagnier and Ara G. Hovanessian},
  journal={Virology},
  year={1991},
  volume={185 2},
  pages={
          829-39
        }
}
Large amounts of histones, H1, H2A, H2B, H3, and H4, were observed in total extracts of T4 lymphocytes and derived cell lines infected with the human immunodeficiency virus (HIV) type 1 or type 2. These histones were simply detectable by analysis of crude cellular extracts by polyacrylamide gel electrophoresis in SDS and staining the proteins with Coomassie blue or by immunoblot assays using specific polyclonal antibodies. The histones were found to be localized in the nucleoplasm, bound to low… CONTINUE READING
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