The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.

Abstract

Thymic graft-versus-host disease (tGVHD) can contribute to profound T cell deficiency and repertoire restriction after allogeneic BM transplantation (allo-BMT). However, the cellular mechanisms of tGVHD and interactions between donor alloreactive T cells and thymic tissues remain poorly defined. Using clinically relevant murine allo-BMT models, we show here… (More)
DOI: 10.1172/JCI39395

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