The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro.

Abstract

We analyzed the development of cytokine-producing effector T cells from resting CD4 memory cells. Previously we showed that such memory effectors are induced in vivo upon re-exposure to Ag. Here we demonstrate that effectors arise in vitro when memory CD4 cells are restimulated with Ag in the presence cytokines. Resting splenic CD4 cells from KLH-primed… (More)

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@article{Bradley1995TheCI, title={The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro.}, author={Lloyd Bradley and Katsuhiko Yoshimoto and Subhashisa Swain}, journal={Journal of immunology}, year={1995}, volume={155 4}, pages={1713-24} }