The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP

@inproceedings{Takahashi2017TheCP,
  title={The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP},
  author={Noriyuki Takahashi and Takayuki Saitoh and Nanami Gotoh and Yasuhiro Nitta and Lobna Alkebsi and Tetsuhiro Kasamatsu and Yusuke Minato and Akihiko Yokohama and Norifumi Tsukamoto and Hiroshi Handa and Hirokazu Murakami},
  booktitle={BMC Immunology},
  year={2017}
}
T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of Th1/Th2 cytokine and cytokine receptor functional polymorphisms on both susceptibility to, and severity of, cITP. We analysed IFN-γ + 874 T/A, IFN-γR -611G/A, IL-4 -590C/T, and IL-4Rα Q576R polymorphisms in 126 cITP patients (male/female: 34/92; median age: 47.7 years) and 202 healthy control donors. Genotyping was determined by PCR and… CONTINUE READING
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