The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation.

@article{Hensellek2007TheCT,
  title={The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation.},
  author={Susanne Hensellek and Patrice Brell and H. -G. Schaible and Rolf Br{\"a}uer and Gisela Segond von Banchet},
  journal={Molecular and cellular neurosciences},
  year={2007},
  volume={36 3},
  pages={381-91}
}
TNFalpha is involved in the generation of hyperalgesia in pathological states such as neuropathy and inflammation. The pronociceptive action of TNFalpha may be mediated at least in part by activation of the TRPV1 receptor which transduces heat stimuli in primary nociceptive afferents and mediates thermal hyperalgesia. In the present study, we investigated in cultured dorsal root ganglion (DRG) neurones, the somata of primary afferent fibres, whether TNFalpha increases TRPV1 receptor expression… CONTINUE READING