The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans.

@article{Danielson2002TheCP,
  title={The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans.},
  author={Phillip B. Danielson},
  journal={Current drug metabolism},
  year={2002},
  volume={3 6},
  pages={561-97}
}
Cytochrome p450s comprise a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions… CONTINUE READING
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