The cytochrome 2C19*2 and *3 alleles attenuate response to clopidogrel similarly in East Asian patients undergoing elective percutaneous coronary intervention.

@article{Hwang2011TheC2,
  title={The cytochrome 2C19*2 and *3 alleles attenuate response to clopidogrel similarly in East Asian patients undergoing elective percutaneous coronary intervention.},
  author={Seok-Jae Hwang and Young Hoon Jeong and In-suk Kim and Jin-Sin Koh and Min-Kyung Kang and Yongwhi Park and Choong Hwan Kwak and Jin-Yong Hwang},
  journal={Thrombosis research},
  year={2011},
  volume={127 1},
  pages={23-8}
}
INTRODUCTION Carriage of CYP2C19*2 allele is associated with diminished platelet response to clopidogrel. However, the loss-of-function impact of CYP2C19*3 allele on antiplatelet effect of clopidogrel has not been definitely verified. We conducted this study to compare decreased response to clopidogrel according to carriage of CYP2C19*2 vs. *3 allele. MATERIALS AND METHODS The study included 190 consecutive Korean patients undergoing elective percutaneous coronary intervention. Light… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Direct evidence for the higher frequency of CYP2C19 allelic heterozygotes in Chinese subjects than in white subjects

HG Xie
Clin Pharmacol Ther 1997;62:691–2 • 1997
View 11 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…