The cytidine mechanism and methylation pathway in the formation of N-methylated ethanolamine phosphoglycerides in Neurospora crassa

@article{Matysiak2005TheCM,
  title={The cytidine mechanism and methylation pathway in the formation of N-methylated ethanolamine phosphoglycerides in Neurospora crassa},
  author={Zdzisław Matysiak and A Radomi{\~n}ska-pyrek and Tadeusz Chojnacki},
  journal={Molecular and Cellular Biochemistry},
  year={2005},
  volume={3},
  pages={143-151}
}
SummaryInNeurospora crassa, phospholipids containing ethanolamine, monomethylaminoethanol, dimethylaminoethanol and choline are formed by a pathway involving cytidine nucleotides. The rate of formation of these phospholipids does not appear to be dependent on the fatty acid composition of diacylglycerols acting as acceptors of phosphorylated aminoethanols. The presence of choline in the growth medium represses the activity of enzymes of the methylation pathway for the biosynthesis of 1,2-diacyl… Expand
1 Citations
Carp head kidney leukocytes display different patterns of oxygen radical production after stimulation with PAMPs and DAMPs.
TLDR
The capacity of hydrogen peroxide to influence the fate of tissue regeneration through the establishment of environments suitable for promoting either tissue regeneration or oxidative stress and thereby potential tissue damage is elucidated. Expand

References

SHOWING 1-10 OF 27 REFERENCES
The synthesis of cytidine diphosphate choline, cytidine diphosphate ethanolamine, and related compounds.
  • E. P. Kennedy
  • Medicine, Chemistry
  • The Journal of biological chemistry
  • 1956
TLDR
This paper will describe the synthesis by chemical procedures of CDP-choline, CDPethanolamine, and some closely related nucleotides, ADP- choline, UDPcholine and GDP-Choline, and the usefulness of DCC as a reagent for the preparation of diesters of pyrophosphoric acid. Expand
Choline and serine incorporation into the phospholipids of Neurosopora crassa.
TLDR
Fungi appear to synthesize phosphatidylethanolamine in a manner similar to that found in gram negative bacteria and animal tissues, indicating that choline is incorporated intact into phosph atidylcholine by an alternate route compared to the normal pathway which involves the methylation of phosphati-dylethanlamine. Expand
Enzymatic Synthesis of Labelled Cytidine-5′-Diphosphate Ethanolamine
TLDR
The method described here, use has been made of the enzyme CTP : ethanolamine-phosphate cytidylyltransferase (EC.7.14) from rat liver, to prepare cytidine-5′-diphosphate-(2-14C)-ethanolamine and cytidine -5′-(β-32P)-diph phosphate ethanolamine in high yield. Expand
Regulation of Phosphatidylcholine Biosynthesis in Saccharomyces cerevisiae
TLDR
Evidence is presented which indicates that the biosynthesis of phosphatidylcholine by the methylation pathway in growing cultures of Saccharomyces cerevisiae is repressed by the presence of choline, suggesting a regulatory effect similar to that demonstrated for the wild-type strain. Expand
The function of cytidine coenzymes in the biosynthesis of phospholipides.
TLDR
The ratio of P32 to Cl4 in the product was closely similar to that of the labeled P-choline, suggesting incorporation of both phosphorus and choline as an intact unit into a phospholipide, presumably lecithin. Expand
The labeling of brain ethanolamine phosphoglycerides from cytidine diphosphate ethanolamine in vitro
TLDR
The enzymic activities which convert CDPE to diacyl GPE and alkenyl acyl GPE, respectively, are similar and formed 10-fold and almost totally confined to the diacylsn-glycero-3-phosphorylethanolamine (GPE). Expand
STUDIES ON THE CDP‐ETHANOLAMINE‐1,2‐DIGLYCERIDE ETHANOLAMINEPHOSPHOTRANSFERASE OF RAT BRAIN
TLDR
Although diacyl glycerol inhibited the formation of ethanolamine plasmalogen the inhibition was not a simple competitive one and the activity was maximal during the period of active myelination but at 3 days and 150 days of age it was at least 50 percent of this maximal activity. Expand
THE FORMATION OF PHOSPHOLIPIDS CONTAINING UNNATURAL BASES BY THE CYTIDINE PATHWAY
TLDR
Experiments indicate, not only a considerable lack of specificity in the enzymes responsible for the biosynthesis of phospholipids, but also that such lipids containing unnatural components can function in vivo. Expand
The incorporation of the phosphate esters of N-substituted aminoethanols into the phospholipids of brain and liver.
TLDR
The cytidylyltransferases of brain and liver are less effective in forming the cytidine diphosphate esters of monomethylaminoethanol and dimethylamino ethanol than those of ethanolamine and choline. Expand
The biosynthesis of choline and its relation to phospholipid metabolism.
The biosynthesis of choline has been studied in the rat with [3-14C]serine, [1,2-14C]-aminoethanol and [14CH3]methionine as precursors. When [14C]aminoethanol was given to intact rats, radioactiveExpand
...
1
2
3
...