The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

@article{Zhang2003TheCD,
  title={The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA},
  author={Hui Zhang and Bin Yang and Roger J. Pomerantz and Chune Zhang and Shyamala C. Arunachalam and Ling Gao},
  journal={Nature},
  year={2003},
  volume={424},
  pages={94-98}
}
High mutation frequency during reverse transcription has a principal role in the genetic variation of primate lentiviral populations. It is the main driving force for the generation of drug resistance and the escape from immune surveillance. G to A hypermutation is one of the characteristics of primate lentiviruses, as well as other retroviruses, during replication in vivo and in cell culture. The molecular mechanisms of this process, however, remain to be clarified. Here, we demonstrate that… CONTINUE READING
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