The cystine/glutamate antiporter system xc− drives breast tumor cell glutamate release and cancer-induced bone pain

@inproceedings{Slosky2016TheCA,
  title={The cystine/glutamate antiporter system xc− drives breast tumor cell glutamate release and cancer-induced bone pain},
  author={Lauren M. Slosky and Neemah M Bassirirad and Ashley M. Symons and Michelle L. Thompson and Timothy P Doyle and Brittany L. Forte and William D. Staatz and Lynn Bui and William L Neumann and Patrick W Mantyh and Daniela Salvemini and Tally Marie Largent-Milnes and Todd W. Vanderah},
  booktitle={Pain},
  year={2016}
}
Bone is one of the leading sites of metastasis for frequently diagnosed malignancies, including those arising in the breast, prostate and lung. Although these cancers develop unnoticed and are painless in their primary sites, bone metastases result in debilitating pain. Deeper investigation of this pain may reveal etiology and lead to early cancer detection. Cancer-induced bone pain (CIBP) is inadequately managed with current standard-of-care analgesics and dramatically diminishes patient… CONTINUE READING