The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A.

@article{Thelin2005TheCF,
  title={The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A.},
  author={William R. Thelin and Mehmet Kesimer and Robert Tarran and Silvia M. Kreda and Barbara R. Grubb and John Kieran Sheehan and M Jackson Stutts and Sharon L. Milgram},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 50},
  pages={41512-20}
}
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated chloride channel expressed at the apical surface of epithelia. Although the regulation of CFTR by protein kinases is well documented, channel deactivation by phosphatases is not well understood. We find that the serine/threonine phosphatase PP2A can physically associate with the CFTR COOH terminus. PP2A is a heterotrimeric phosphatase composed of a catalytic subunit and two divergent regulatory subunits (A and B… CONTINUE READING