The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma.

@article{Hao2006TheCT,
  title={The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma.},
  author={Liwei Hao and Ian Sayers and Julie A. Cakebread and S J Barton and Bianca Begh{\'e} and Stephen T. Holgate and Anthony Peter Sampson and John W Holloway},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2006},
  volume={36 6},
  pages={735-41}
}
BACKGROUND The cysteinyl-leukotriene receptor type 1 (CysLT1) mediates the bronchoconstrictor and pro-inflammatory actions of cysteinyl-leukotrienes (LTC4, LTD4, LTE4) in asthma and is the molecular target of the lukast class of oral anti-leukotriene drugs. We screened the CYSLTR1 gene on chromosome Xq13-21 for coding region polymorphisms, and investigated their associations with allergy and asthma. METHODS Solid-phase chemical cleavage was used to screen polymorphisms in the coding region of… CONTINUE READING
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