The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

@article{Wart1990TheCS,
  title={The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.},
  author={Harold E Van Wart and Henning Birkedal-Hansen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 14},
  pages={5578-82}
}
The general applicability of the "cysteine-switch" activation mechanism to the members of the matrix metalloproteinase (MMP) gene family is examined here. All currently known members of the MMP gene family share the characteristic that they are synthesized in a latent, inactive, form. Recent evidence suggests that this latency in human fibroblast collagenase (HFC) is the result of formation of an intramolecular complex between the single cysteine residue in its propeptide domain and the… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
348 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 348 extracted citations

Similar Papers

Loading similar papers…