The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling.

@article{Gibbs2006TheCS,
  title={The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling.},
  author={Gerard M. Gibbs and Martin J Scanlon and James D. Swarbrick and Suzanne Curtis and Esther M. Gallant and Angela F Dulhunty and Moira K O'Bryan},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 7},
  pages={4156-63}
}
The cysteine-rich secretory proteins (Crisp) are predominantly found in the mammalian male reproductive tract as well as in the venom of reptiles. Crisps are two domain proteins with a structurally similar yet evolutionary diverse N-terminal domain and a characteristic cysteine-rich C-terminal domain, which we refer to as the Crisp domain. We presented the NMR solution structure of the Crisp domain of mouse Tpx-1, and we showed that it contains two subdomains, one of which has a similar fold to… CONTINUE READING

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