The cysteine-rich protein gene family of Giardia lamblia: loss of the CRP170 gene in an antigenic variant.

@article{Adam1992TheCP,
  title={The cysteine-rich protein gene family of Giardia lamblia: loss of the CRP170 gene in an antigenic variant.},
  author={Rodney D. Adam and Yoon Mo Yang and Theodore Elliott Nash},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 3},
  pages={
          1194-201
        }
}
Giardia lamblia trophozoites demonstrate variable expression of a repertoire of cysteine-rich surface antigens in vitro and in vivo. The size of the repertoire has been estimated at 20 to 184, and specific variants can be detected after approximately 12 generations of in vitro growth for the WB isolate. In earlier studies, we cloned a portion of the gene for a 170-kDa surface antigen (CRP170) and demonstrated by DNA sequencing that it was cysteine rich (12%) and contained 2.6 copies of a… CONTINUE READING

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