The cysteine-rich domain of human T1R3 is necessary for the interaction between human T1R2-T1R3 sweet receptors and a sweet-tasting protein, thaumatin.

@article{Ohta2011TheCD,
  title={The cysteine-rich domain of human T1R3 is necessary for the interaction between human T1R2-T1R3 sweet receptors and a sweet-tasting protein, thaumatin.},
  author={Keisuke Ohta and Tetsuya Masuda and Fumito Tani and Naofumi Kitabatake},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={406 3},
  pages={435-8}
}
Thaumatin is an intensely sweet-tasting protein perceived by humans but not rodents. Its threshold value of sweetness in humans is 50nM, the lowest of any sweet-tasting protein. In the present study, the sites where sweet receptors interact with thaumatin were investigated using human embryonic kidney 293 (HEK293) cells expressing the sweet receptors T1R2… CONTINUE READING