The cysteine-rich domain of TET2 binds preferentially to mono- and dimethylated histone H3K36

Abstract

Missense mutations in Ten-eleven translocation 2 (TET2) gene are frequently found in leukaemia patients. Although mutations span the entire coding region, they tend to cluster in the C-terminal enzymatic domain and a cysteine-rich (CR) domain of unknown function. Herein, we found the CR domain binds chromatin preferentially at the histone H3 tail by… (More)
DOI: 10.1093/jb/mvx004

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