The cysteine residues of the M2 protein are not required for influenza A virus replication.

@article{Castrucci1997TheCR,
  title={The cysteine residues of the M2 protein are not required for influenza A virus replication.},
  author={Maria Rita Castrucci and Michelle M. Hughes and Laura Calzoletti and Isabella Donatelli and Krisna Wells and Ayato Takada and Yoshihiro Kawaoka},
  journal={Virology},
  year={1997},
  volume={238 1},
  pages={128-34}
}
The M2 protein of influenza A virus functions as an ion channel. It contains three cysteine residues: cysteines 17 and 19, which form disulfide bonds in the ectodomain, and cysteine 50 which is acylated. To understand the role of these cysteine residues in virus replication, we used reverse genetics to create influenza viruses in which the individual cysteines were mutated and a virus in which all three cysteines were changed to serine. The M2 cysteine mutants that lacked either of the cysteine… CONTINUE READING

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