The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli.

@article{Schwartz2000TheCD,
  title={The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli.},
  author={Colin J. Schwartz and Ouliana Djaman and James A. Imlay and Patricia Kiley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 16},
  pages={9009-14}
}
The cysteine desulfurase, IscS, provides sulfur for Fe-S cluster synthesis in vitro, but a role for IscS in in vivo Fe-S cluster formation has yet to be established. To study the in vivo function of IscS in Escherichia coli, a strain lacking IscS was constructed and characterized. Using this iscS deletion strain, we have observed decreased specific activities for proteins containing [4Fe-4S] clusters from soluble (aconitase B, 6-phosphogluconate dehydratase, glutamate synthase, fumarase A, and… CONTINUE READING
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