The cyclops and the mermaid: an epidemiological study of two types of rare malformation.

@article{Klln1992TheCA,
  title={The cyclops and the mermaid: an epidemiological study of two types of rare malformation.},
  author={Bengt K{\"a}ll{\'e}n and Eduardo Enrique Castilla and P. A. L. Lancaster and Osvaldo M. Mutchinick and Lisbeth B. Knudsen and M L Martinez-frias and Pierpaolo Mastroiacovo and Elisabeth Robert},
  journal={Journal of medical genetics},
  year={1992},
  volume={29 1},
  pages={30-5}
}
Infants with cyclopia or sirenomelia are born at an approximate rate of 1 in 100,000 births. Eight malformation monitoring systems around the world jointly studied the epidemiology of these rare malformations: 102 infants with cyclopia, 96 with sirenomelia, and one with both conditions were identified among nearly 10.1 million births. Maternal age is somewhat increased for cyclopia, indicating the likely inclusion of some chromosomally abnormal infants which were not identified. About half of… CONTINUE READING