The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.

@article{Bergsma1991TheCM,
  title={The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.},
  author={Derk J. Bergsma and C Eder and Mitchell Gross and Helga Kersten and Daniel Sylvester and Edward Appelbaum and D M Cusimano and George P. Livi and Megan M. McLaughlin and K J Kasyan},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 34},
  pages={23204-14}
}
Cyclophilin (CyP), a major cytosolic protein possessing peptidyl-prolyl cis-trans isomerase activity, has been implicated as the specific receptor of the immunosuppressive drug cyclosporin A (CsA). To identify other potential CsA receptors related to CyP, two human cDNA libraries were screened under low stringency conditions using human CyP cDNA (encoding hCyP1) as a probe. Two cDNAs were identified which encode distinct proteins related to human hCyP1. These two novel proteins, designated… CONTINUE READING
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