The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat.

@article{Cuzzocrea2003TheCP,
  title={The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat.},
  author={Salvatore Cuzzocrea and Angela Ianaro and Nicole S. Wayman and Emanuela Mazzon and Barbara Pisano and Laura Dugo and Ivana Serraino and Rosanna di Paola and Prabal Kumar Chatterjee and Massimo Di Rosa and Achille Patrizio Caputi and Christoph Thiemermann},
  journal={British journal of pharmacology},
  year={2003},
  volume={138 4},
  pages={
          678-88
        }
}
1. Inflammatory bowel disease (IBD) is characterized by oxidative and nitrosative stress, leukocyte infiltration, and increased expression of the adhesion molecules intercellular adhesion molecule 1 (ICAM-1) in the colon. Recent evidence also suggests that the cyclopentenone prostaglandin (PG) 15-deoxy-delta(12,14)-PGJ(2) (15d- PGJ(2)) functions as an early anti-inflammatory signal. 2. The aim of the present paper is to investigate the effects of 15d-PGJ(2) in rats subjected to experimental… CONTINUE READING

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