The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1.

@article{GoddenKent1997TheCE,
  title={The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1.},
  author={Diana Godden-Kent and Simon J. Talbot and Chris H. Boshoff and Yuan - Chia Chang Yeun - Chung Chang Chin - Chen Chang and Paul Moore and Robin A Weiss and Sibylle Mittnacht},
  journal={Journal of virology},
  year={1997},
  volume={71 6},
  pages={4193-8}
}
Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) is a novel gammaherpesvirus implicated in the cause of Kaposi's sarcoma and certain malignancies of lymphatic origin. One of the candidate genes possibly involved in promoting tumor development is an open reading frame (ORF) with sequence similarity to human type D cyclin genes. This cyclin-like gene, when expressed in tissue culture cells, promotes phosphorylation and inactivation of the retinoblastoma tumor suppressor… CONTINUE READING

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Cloning of p 27 Kip 1 , a cyclin - dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

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