The cyclin-dependent protein kinases and the control of cell division.

@article{Dore1994TheCP,
  title={The cyclin-dependent protein kinases and the control of cell division.},
  author={Marcel Dor{\'e}e and Simon Galas},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1994},
  volume={8 14},
  pages={1114-21}
}
A few years after the identification of cyclin B-cdc2 kinase as the universal factor that controls onset of M-phase in eukaryotic cells, MPF (M-phase promoting factor), it became evident that all transitions of the cell cycle are controlled through phosphorylation of specific targets due to changes in the activity of a variety of cyclin-dependent kinases (cdks). These transitions include conversion of quiescent cells to a state of active proliferation, commitment to DNA replication, initiation… CONTINUE READING