The cyclin-dependent kinase inhibitors p27Kip1 and p21Cip1 are not essential in T cell anergy.

@article{Verdoodt2003TheCK,
  title={The cyclin-dependent kinase inhibitors p27Kip1 and p21Cip1 are not essential in T cell anergy.},
  author={Berlinda Verdoodt and Tino Blazek and Pia Rauch and Gerold Schuler and Alexander Steinkasserer and Manfred B Lutz and Jens Oliver Funk},
  journal={European journal of immunology},
  year={2003},
  volume={33 11},
  pages={3154-63}
}
Recent evidence suggests that the cyclin-dependent kinase (Cdk) inhibitors p27Kip1 and p21Cip1 are important factors in T cell anergy, but it has remained unclear whether anergy can be induced in their absence. We therefore induced anergy by stimulation of purified T cells from wild-type, p21Cip1-/-, and p27Kip1-/- mice with anti-CD3 antibodies. Anergic wild-type T cells were arrested in the G1 phase of the cell cycle with a high p27Kip1 protein level and low Cdk2 activity. In p27-/- and p21… CONTINUE READING
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