The cyclic AMP system andDrosophila learning

@article{Davis1995TheCA,
  title={The cyclic AMP system andDrosophila learning},
  author={Ronald L. Davis and Jim Cherry and Brigitte Dauwalder and P Han and Efthimios M C Skoulakis},
  journal={Molecular and Cellular Biochemistry},
  year={1995},
  volume={149},
  pages={271-278}
}
The cyclic AMP (cAMP) system plays a critical role in olfactory learning in the fruit fly,Drosophila melanogaster, as evidenced by the following: [1] The dunce gene encodes a form of cAMP phosphodiesterase (PDE). Flies carrying mutations at this gene show reduced PDE activity, high cAMP levels, and deficits in olfactory learning and memory [2]. The rutabaga gene encodes one type of adenylyl cyclase (AC) similar in properties to the Type I AC characterized from vertebrate brain. This enzyme is… CONTINUE READING

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A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepresssant drugs

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