The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas☆


Amoebas survive environmental stress by differentiating into encapsulated cysts. As cysts, pathogenic amoebas resist antibiotics, which particularly counteracts treatment of vision-destroying Acanthamoeba keratitis. Limited genetic tractability of amoeba pathogens has left their encystation mechanisms unexplored. The social amoeba Dictyostelium discoideum… (More)
DOI: 10.1016/j.cellsig.2013.10.008


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