The cyanotoxin-microcystins: current overview

  title={The cyanotoxin-microcystins: current overview},
  author={Rajesh P Rastogi and Rajeshwar Prasad Sinha and Aran Incharoensakdi},
  journal={Reviews in Environmental Science and Bio/Technology},
The monocyclic heptapeptides microcystins (MCs), are a group of hepatotoxins, produced worldwide by some bloom-forming cyanobacterial species/strains both in marine and freshwater ecosystems. MCs are synthesized non-ribosomally by large multi-enzyme complexes consisting of different modules including polyketide synthases and non-ribosomal peptide synthetases, as well as several tailoring enzymes. More than 85 different variants of MCs have been reported to exist in nature. These are chemically… 

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The toxicology of microcystins.

  • R. Dawson
  • Biology, Chemistry
    Toxicon : official journal of the International Society on Toxinology
  • 1998

Bioremediation of cyanotoxins.

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