The cutaneous nerve biopsy: technical aspects, indications, and contribution.

@article{Mellgren2013TheCN,
  title={The cutaneous nerve biopsy: technical aspects, indications, and contribution.},
  author={Svein Ivar Mellgren and Maria Nolano and Claudia Sommer},
  journal={Handbook of clinical neurology},
  year={2013},
  volume={115},
  pages={
          171-88
        }
}
Skin biopsy with a 3mm disposable circular punch is easy to perform and allows, after proper processing, the visualization of epidermal, dermal, and sweat gland nerve fibers. A technique of sampling the epidermis alone by applying a suction capsule, the "blister" technique, has also been developed. It is most common to stain immunohistochemically for the pan-axonal marker protein gene product 9.5 (PGP 9.5), an ubiquitin C-terminal hydroxylase. The sections are then observed and analyzed with… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 106 REFERENCES

Myelinated nerve endings in human skin.

  • Muscle & nerve
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Small nerve fiber involvement in SLE: a controlled study

R Omdal, SI Mellgren, L G ransson
  • Arthritis Rheum 46: 1228–1232. rstavik K, Norheim I, J rum E (2006). Pain and small-fiber neuropathy in patients with hypothyroidism. Neurology 67:
  • 2002
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

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