The curry spice curcumin attenuates beta-amyloid-induced toxicity through beta-catenin and PI3K signaling in rat organotypic hippocampal slice culture.

@article{Hoppe2013TheCS,
  title={The curry spice curcumin attenuates beta-amyloid-induced toxicity through beta-catenin and PI3K signaling in rat organotypic hippocampal slice culture.},
  author={Juliana Bender Hoppe and Rudimar Luiz Frozza and Elisa Nicoloso Sim{\~o}es Pires and Andr{\'e} Bevilacqua Meneghetti and Christianne Gazzana Salbego},
  journal={Neurological research},
  year={2013},
  volume={35 8},
  pages={
          857-66
        }
}
OBJECTIVE Accumulating evidence indicates that curcumin potently protects against beta-amyloid (Abeta) due to its oxygen free radicals scavenging and anti-inflammatory properties. However, cellular mechanisms that may underlie the neuroprotective effect of curcumin in Abeta-induced toxicity are not fully understood yet. The present study was undertaken to investigate the mechanisms involved in neuroprotective effects of curcumin, particularly involving Wnt/beta-catenin and PI3K pathways… CONTINUE READING
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